Methotrexate plus narrowband UVB phototherapy versus narrowband UVB phototherapy alone in the treatment of plaque-type psoriasis: a randomized, placebo-controlled study

Asawanonda P, Nateetongrungsak Y

J Am Acad Dermatol 2006; 54:1013-8 doi:

The treatment options for psoriasis vary, and with each option there is an associated risk. Fortunately, all of the risks that have been found are associated with extended long-term use of the therapy. Due to this, combination therapy is often implemented. This allows a patient to experience accelerated improvement in their psoriasis, while being exposed to fewer doses of each modality. The study conducted by Aswanonda and Nateetongrungsak concluded, “Short-term adverse effects associated with this treatment combination are not different from when either treatment is used alone.”