Narrow-band UVB Phototherapy Linked to Suppression of the IFN and Th17 Pathways

Full Article

Emoke Rácz 1, Errol P Prens, Dorota Kurek, Marius Kant, Dick de Ridder, Sabine Mourits, Ewout M Baerveldt, Zeliha Ozgur, Wilfred F J van IJcken, Jon D Laman, Frank J Staal, Leslie van der Fits

Narrow-band ultraviolet-B (NB-UVB) phototherapy is an effective treatment for psoriasis. The molecular mechanisms underlying its efficacy are incompletely understood. To identify NB-UVB-induced molecular pathways that may account for its anti-inflammatory efficacy, gene expression profiling was performed using epidermal RNA from lesional and nonlesional skin from patients with psoriasis undergoing NB-UVB therapy. Downregulation of Th17 signaling pathway was observed during NB-UVB therapy in psoriatic epidermis.