FDA issues boxed warning for efalizumab

Fiore K

Medpage Today. 2008.

Much like other biologics, efalizumab (Raptiva) carries a risk of infections that could be life-threatening, which comprises of progressive multifocal leukoencephalopathy (PML). Most biologics are immunosuppressive in order to decrease the flare ups associated with psoriasis, however this enhances the risk of contracting serious infection.